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Questions, experiences and reviews (17)

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Monotrate 10 (Isosorbide mononitrate) after bypass?
My mother has undergone a heart bypass surgery after which a doc told her to have Monotrate 10 (Isosorbide mononitrate).

Recently when she went to regular doc for taking medicines for cold the doc told her as to why she is having Monotrate 10 (Isosorbide mononitrate) since she has already gone thru the bypass.

I am confused.

Please help.


Regards,
JIM
jimmythakkar
05/26/09
Reply
  Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased.
Consult your doctor.
gangadharan nair
05/26/09
isosorbide mononit possible side effect?
my wife just started taking the drug isosorbide mononit and she is seeing brite strips of light out the corners of her eyes? is this harmful or will the symptoms go away?
tezas n
11/19/07
Reply
  The pain of coronary heart disease (angina) usually occurs when the heart requires more blood and oxygen than its blood vessels supplying the heart can deliver. The demand for oxygen can be reduced and pain prevented in one of two ways. First, by dilating the veins and allowing more blood to "pool." This reduces the amount of blood returning to the heart and hence the heart's work and need for oxygen. Second, by dilating the arteries of the body and reducing the pressure within the arteries. This reduces the pressure that the heart has to pump against and hence the Heart's work and need for oxygen. Isosorbide mononitrate reduces angina by dilating both the veins and the arteries.

Isosorbide mononitrate also increases supply of oxygen to the heart by dilating the arteries which supply the heart itself. Isosorbide mononitrate is in the class of drugs called anti-anginal medications. Isosorbide mononitrate is the chief metabolite of isosorbide dinitrate, and most of the activity of isosorbide dinitrate is due to its metabolite, isosorbide mononitrate.

Since isosorbide mononitrate can cause hypotension (low blood pressure), other medications which can reduce blood pressure may produce additive effects causing serious drops in blood pressure. Such drugs might include those used to treat high blood pressure, some antidepressants; some anti-psychotics, quinidine, procainamide, benzodiazepines such as diazepam (Valium) or opiates (e.g. morphine).

Since ethanol also may intensify the blood pressure lowering effect of isosorbide mononitrate, patients receiving isosorbide mononitrate should be advised to use ethanol with caution.

I would certainly report these symptoms to her physcian. It could be a harmless side effect, but it needs to be reported.
chamie
11/19/07
Patient with congestive heart failure taking enalapril, furosemid and isosorbide, has persistent dry non cough?
The patient is on enalapril, furosemid and isosorbide. While talking with the client, te nurse notices that the client has a persistent dry, nonproductive cough. What nursing action is most apporpriate?

A. Ask if client is taking any cough meds
B. Encourage the client to increase flid intake
C. Ask if the client has experienced any chest pain.
D. Notify the physician

What is your rationale/reason for your choice
Rochelle M
06/17/09
Reply
  ENALAPRIL..Most common side effects include hypotension, dizziness when standing up, dry cough
FUROSEMID..Side effects

Frequent urination may last for up to 6 hours after a dose and should decrease after you take furosemide for a few weeks. Tell your doctor if any of these symptoms are severe or do not go away:

muscle cramps

weakness

dizziness

confusion

thirst

upset stomach

vomiting

blurred vision

headache

restlessness

constipation
ISOSORBIDE......Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Headache.
Dizziness.
Weakness.
Nausea.
Flushing.
A drop in blood pressure that occurs when moving from a lying down or sitting position to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).
Increased heart rate (tachycardia).
Decreased heart rate (bradycardia).
Allergic skin reactions.
Fainting.
nutterorsaintuchoose
06/17/09
Can I eat grapefruit while taking Isosorbide?
Sharon P
02/15/10
Reply
  Grapefruit and grapefruit juice are known to interact with many medications due to competition with enzymes in the liver. The package insert for Isosorbide Mononitrate and Dinitrate states "Avoid grapefruit and grapefruit juice." I ran Isorbide Mononitrate and Dinitrate in various drug interaction checkers and there was no known interaction though. I would suggest you avoid grapefruit though, because it can also interact with many other medications.
Agnodice
02/19/10
what is the disadvantages by using isosorbide dinitrate?
hui xin
01/05/08
Reply
  Get the package insert and read it or call the physcian for some patient teachng information on the medication. This should not have been prescribed wthout a patient teaching.
kmr1234
01/05/08
what is isosorbide dinitrate (isoket spray) ?
hui xin
01/05/08
Reply
  It is used for angina (chest pain). Isosorbide dinitrate works by releasing a chemical called nitric oxide. This chemical is also made naturally by the body and has the effect of making the veins and arteries relax and widen (dilate). This increases the space within the blood vessels and therefore reduces the resistance within the blood vessels, which makes it easier for the heart to pump blood around the body.
Tracy S
01/05/08
what is isosorbide mn 60 mg use for?
pharmacy say`s it`s nitrostat.
and another say`s it`s a blood thinner
breakcreakfreak@yahoo.com
06/18/09
Reply
  From Medline:

Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased.
Sheri
06/18/09
why am i told to take my 2 daily doses of isosorbide dinitrate no more than 7 hours apart?
wondered
11/29/06
Reply
  In order for it to work well the level within your body must be maintained constantly so after7 hours the amount significantly decreases so your next dose will not be as effective...
saphire18
11/29/06
Where can I find "Imazin XL Forte"?
IT IS ISOSORBIDE MONONITRATE SR with ASPIRIN.
shadow
06/20/06
Reply
  is it a otc drug
sekharssajja
06/20/06
how long after ceasing dosage of isosorbide mononitrate does it take to clear your system?
Nollie R
01/26/10
Reply
  It depends on the type tablet you take and duration of use:

# If it is ordinary tablet, Isosorbide mononitrate has an elimination half-life of around five hours.

# Sustained Release tablets results in a gradual, non-pH dependent release of the active substance, which is completed after approximately ten hours. Compared to ordinary tablets, the absorption phase is prolonged and the duration of effect is extended. Which means that to clear out completely it takes 10+5 = 15 hours.

# After repeated once daily administration of GenRx Isosorbide Mononitrate Sustained Release tablets, the maximum plasma level (about 3,000 nanomol/L) of isosorbide mononitrate is achieved at about four hours. The plasma concentration remains above 1,400 to 1,500 nanomol/L for approximately ten hours, dropping to under 500 nanomol/L by the end of the dosage interval (24 hours after dose).

So in such a case it takes just over 24 hours.
Queryman
01/26/10
Adrenosine Nuclear test preparation question.?
This afternoon (Friday) I was scheduled for an Adrenosine Nuclear [Pharmacological Myocardial Profusion (MPI) rest/stress study using Adrenosine] at 7:30 Monday morning. Since my cardiologist's office is not open during the weekend, I cannot ask him before the test.

The instruction sheet I received says "Take medications as prescribed unless otherwise directed by your physician."

The Cleveland Clinic (not involved in my test) instruction sheet says:

"If you take heart medications: DO NOT take the following heart medications on the day of the test unless your physician tells you otherwise, or unless it is needed to treat chest discomfort the day of the test:
Isosorbide dinitrate (for example: Dilatrate, Isordil)
Isosorbide mononitrate (for example: Imdur, ISMO, Monoket)
Nitroglycerin (for example: Minitran, Nitropatches, Nitrostat)
Dipyridamole (Persantine) -- Stop taking 48 hours before the test
Your physician may also ask you to stop taking other heart medications on the day of your test. If you have any questions about your medications, ask your physician. Do not discontinue any medication without first talking with your physician."

I take Isosorbide mononitrate (Imdur), usually about 7:30 in the morning, shortly after I normally get up. Obviously Monday morning I will be getting up earlier.

I have not decided if it would be better to take my normal dose shortly after I get up Monday or if it would be better to take the tablet with me to the appointment as ask if they want me to delay taking it until after the test. My concerns are:

If they want me to take it before the test, and I do not take it until 7:30, will they have to delay the start of the test until the medication gets into the bloodstream?

If I do take it and they did not want me to, would the test be less valid or postponed?

Any informed advice would be appreciated.
zman492
10/25/08
Reply
  Imdur could possibly interfere with the test results since it causes the blood vessels to dialate and increase blood flow to cardiac tissue. But it is contraindicated to abruptly stop taking Imdur, as it can make symptoms of angina (chest pain) worse.
Call the number you have for your doctor. Listen to the message/recording, they should give a number for the doctor's exchange. It is a way to get ahold of the physicians after hours. Whatever cardiologist is taking call will be able to answer your questions. It's always a good idea to clarify.
It's best to follow whatever their instructions are specifically.
Jessica C
10/25/08
Exactly what is Isosorbide Mononitrate used for?
The cardiologist said every thing looked normal on the different tests so why this medication plus have nitro pills on hand
lorene_c4
11/17/07
Reply
  Isosorbide mononitrate reduces angina by dilating both the veins and the arteries.

Isosorbide mononitrate also increases supply of oxygen to the heart by dilating the arteries which supply the heart itself. Isosorbide mononitrate is in the class of drugs called anti-anginal medications.
Samirah
11/17/07
Is is correct that ISOSORBIDE DINITRATE USP advesely affects a man's sexual abilities? Pl. help.?
I've also heard that over a longer period of its intake it also 'shrinks' the penis in size?
serial_kisser
10/24/06
Reply
  dunno
yagman
10/24/06
Does the drugs Toprol, Isosorbide, and Lotensin create dehydration in the human body?
These drugs are basically blockers and nitrates used in cardiovascular disease.
colleen
01/31/10
Reply
  No, none of these medications cause dehydration. Benzazepril (Lotensin) does not cause dehydration, but dehydration is a concern in people who take it. Dehydration in a person who takes Lotensin can lead to impairment in kidney function. Therefore all patients taking Lotensin should stay well hydrated. If dehydration occurs, then this should be treated promptly and Lotensin should be held until the dehydration is treated.
Agnodice
02/04/10
What can happen if you overdose on isosorbide mn?
i consumed about 360mg all together thinking that it was painkiller, now the symptoms are my ankle area hurts very bad and this morning i had very bad headache and trouble breathing i recover from that but ankle are killing me, will it go away? soon. i am young healthy 22 years old. no health problem at all. PLEASE HELP THANKS.
unkown j
01/08/08
Reply
  As mentioned above, isosorbide monititrate is a type of nitrate. This class of drugs is commonly used to treat heart disease. They work by causing blood vessels to expand. Headache is a common side effect. Too much nitrates may cause low blood pressure, dizziness, and chest pain. Unfortunately, there are different formulations of isosorbide mononitrtate, and you may have taken an extended release form.

I suggest you contact your local poison control for more information or 1-800-POISONS. They will be better able to instruct you on warning signs after accidental overdose and proper treatment. If your symptoms worsen, call 911.
Dr. C
01/08/08
Why does isosorbide dinitrate and hydralazine work in treating congestive heart failure in african americans?
Results from the African-American Heart Failure Trial suggested a strong improvement. I just want to know whether there are any biological justifications found.
cowardjai
11/15/07
Reply
  Seems all very muddy at this stage but there are some findings....

Firstly in 2001, the prevalence of HF was 40% more common in black males than white males (3.5% vs 2.3%) and twice as common in black females as white females (3.1% vs 1.5%).

In this debate, one issue that is commonly confused is the difference between race and ancestry. Ancestry refers to objective genetic relationships between individuals and among populations, whereas race has always been a somewhat arbitrary definition of population boundaries. For example, while an individual might have ancestors from Europe, Africa, and North America, he or she still might be categorized as an African American. Therefore, race captures some biological information about ancestry, but it is not equivalent to ancestry.

Yet clinicians often want to know whether it is valid and reliable to use race as a proxy to infer an individual's genetic risk for disease and treatment response. Whether race matters is, however, complicated because it depends on the relationship between the genetic risk factor, ancestry, and race. For example, beta-blockers and angiotensin-converting enzyme (ACE) inhibitors for hypertension treatment may not work as well, on average, in African Americans compared with European Americans, but both types of drugs appear to work perfectly well in a large fraction of African Americans and poorly in some European Americans.

The observation might be explained by a hypothetical genetic predictor of positive response to ACE inhibitors that is common in European Americans but that is also present in some African Americans because of admixture and absent in some European Americans. In such a case, the best predictor of treatment response might be the presence of the variant (ie, direct testing); the next best might be an accurate estimator of genetic ancestry, and race might be only a poor predictor of genetic risk and therefore treatment response.
Menthoids
11/15/07
how long do I need to wait?
I just stopped taking isosorbide mononitrate for a heart condition. How long do I need to wait before taking viagra?
Jack Sprat
09/18/08
Reply
  You really need to talk to your doctor about this. For one thing, he or she needs to know you stopped taking the isosorbide and decide whether it's safe for you to do so and when and IF it's safe for you to take Viagra. Don't mess around with it. Sex is great but I don't think it's worth risking your health over.
Christy
09/21/08

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